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Mengxi Jiang, Ph.D.

Patent Agent

Dr. Mengxi Jiang, a registered U.S. patent agent at Johnson, Marcou & Isaacs LLC (JMI), is fluent in English and Chinese, and has extensive experience preparing and prosecuting patent applications in pharmaceutical, life science and medical device fields. She has performed freedom-to-operate analysis, IP due diligence and landscape reviews, prior art searches, and counseled clients on patent validity, patent infringement and patentability. She also has been an editorial board member for the Journal of Medical Virology, Clinical Journal of Microbiology & Pathology and the Austin Journal of Microbiologyfor several years, as well as is a frequent ad hoc reviewer for several other biotech publications. 


Prior to joining JMI, Dr. Jiang was a patent agent with Baker Botts LLP in New York, where she worked with multinational and mid-size biopharmaceutical companies, biotech start-ups and research institutions. Before that position, she was a patent consultant with Leason Ellis LLP in White Plains, N.Y., where she utilized both U.S. and Chinese patent resources for patent prior art searches and was responsible for several English-Chinese patent translation projects.


Dr. Jiang was an assistant professor in the Department of Microbiology at The University of Alabama in Birmingham, where she established and managed a research laboratory of seven researchers studying DNA tumor viruses and was awarded for government, foundation and industry sponsored research grants. Prior to that position, she was a research fellow and research investigator in the Department of Microbiology and Immunology at the University of Michigan Medical School in Ann Arbor, Michigan, where she developed diverse research projects in virology, biochemistry, molecular biology, cancer biology and infectious diseases. She also served as a graduate research and teaching assistant in the Department of Molecular, Cellular and Developmental Biology at the University of Michigan, where she developed novel proteomic approaches to study bacterial ribosome biogenesis and taught six semesters of biology, microbiology, genetics and genetics lab courses. 


Dr. Jiang obtained her doctorate in Molecular, Cellular and Developmental Biology at the University of Michigan, and a bachelor of science in biology at Fudan University in Shanghai, China.


  • Bharat A, Jiang M, Sullivan SM, Maddock JR, Brown ED. Cooperative and critical roles for both G domains in the GTPase activity and cellular function of ribosome- associated Escherichia coli EngA. J Bacteriol, 2006. 188(22):7992-6.

  • Jiang M, Datta K, Walker A, Strahler J, Bagamasbad P, Andrews PC, Maddock JR.  The Escherichia coli GTPase CgtAE is involved in late steps of large ribosome assembly.  J Bacteriol, 2006. 188(19):6757-70.

  • Jiang M, Sullivan SM, Walker AK, Strahler JR, Andrews PC, Maddock JR.  Identification of novel Escherichia coli ribosome-associated proteins using isobaric tags and multidimensional protein identification techniques. J Bacteriol, 2007. 189(9):3434-44.

  • Jiang M, Sullivan SM, Wout PK, Maddock JR. G-protein control of the ribosome- associated stress response protein SpoT. J Bacteriol, 2007. 189(17):6140-7

  • Jiang M*, Abend JR*, Johnson SF, Imperiale MJ. The role of polyomaviruses in human disease. Virology, 2009. 384(2): 266-73. (* co-first authors, Virology top cited article 2008- 2010)

  • Jiang M, Abend JR, Tsai B, Imperiale MJ. Early events during BK virus entry and disassembly. J Virol, 2009. 83(3):1350-8.

  • Swimm AI, Bornmann W, Jiang M, Imperiale MJ, Lukacher AE, Kalman D. Abl-family tyrosine kinases regulate sialylated ganglioside receptors for polyomavirus. J Virol, 2010. 84(9):4243-51. (Cover photograph)

  • Abend JR*, Jiang M*, Imperiale MJ. BK virus and human cancer: Innocent until proven guilty. Semin Cancer Biol, 2009. 19(4):252-60. (*co-first authors)

  • Taube S*, Jiang M*, Wobus CE. Glycosphingolipids as receptors for non-enveloped viruses.  Viruses, 2010. 2(4), 1011-49. (*co-first authors)

  • Jiang M, Entezami P, Gamez M, Stamminger T, Imperiale MJ. Functional reorganization of promyelocytic leukemia nuclear bodies during BK virus infection. mBio, 2011. 2 (1), pii: e00281-10. (Cover photograph)

  • Jiang M, Sang X, Hong Z. Beyond nutrients: Food-derived microRNAs provide cross- kingdom regulation. Bioessays, 2012. 34(4):280-4.

  • Jiang M, Imperiale MJ. Design Stars: how small DNA viruses remodel host nucleus.  Future Virology, 2012. 7(5):445-459.

  • Jiang M, Zhao L, Gamez M, Imperiale MJ. Roles of ATM- and ATR-mediated DNA damage response during lytic BK virus infection. Plos Pathogens, 2012. 8(8):e1002898.

  • Bennett SM, Jiang M, Imperiale MJ. Role of cell type-specific ER-associated degradation in polyomavirus trafficking. J Virol, 2013. 87(16):8843-52.

  • Imperiale MJ, Jiang M. What DNA viral genomic rearrangements tell us about persistence. J Virol, 2015. 89(4):1948-1950.

  • Verhalen B, Justice JL, Imperiale MJ, Jiang M. Viral DNA replication-dependent DNA damage response activation during BK polyomavirus infection. J Virol, 2015. 89(9):5032- 9.

  • Justice JL, Verhalen B, Jiang M. Polyomavirus interaction with the DNA damage response.  Virol Sin, 2015. 30(2):122-9.

  • Justice JL, Verhalen B, Kumar R, Lefkowitz EJ, Imperiale MJ, Jiang M. Quantitative proteomic analysis of enriched nuclear fractions from BK polyomavirus-infected primary renal proximal tubule epithelial cells. J Proteome Res, 2015. 14(10):4413-24.

  • Verhalen B, Starrett GJ, Harris RS, Jiang M. Functional upregulation of the DNA cytosine deaminase APOBEC3B by polyomaviruses. J Virol, 2016. 90(14):6379-86. 

  • Imperiale MJ, Jiangk M. Polyomavirus persistence. Annu. Rev. Virol, 2016. 3(1):517-532. 


  • Ph.D., Molecular, Cellular & Developmental Biology, University of Michigan, 2006

  • B.S., Biology, Fudan University, Shanghai, China, 2001


Admitted to Practice

  • United States Patent and Trademark Office

Additional Information


Invited Lectures

  • Novartis Institutes for Biomedical Research. Cambridge, MA. July 6, 2011 

  • Amherst College, Dept. of Biology. Amherst, MA. Nov. 17, 2011 

  • University of Michigan School of Public Health, Dept. of Epidemiology. Ann Arbor, MI. Dec. 6, 2012

  • Texas Tech University, Dept. of Biological Sciences. Lubbock, TX. Feb. 20, 2012

  • Mississippi State University, Dept. of Biological Sciences. Starkville, MS. Feb. 25, 2012 

  • The Ohio State University, Dept. of Veterinary Biosciences. Columbus, OH. March 6, 2012 

  • The University of Alabama at Birmingham, Dept. of Microbiology. Birmingham, AL. April 3, 2012 

  • Tufts University, Dept. of Molecular Biology and Microbiology. Boston, MA. April 11, 2012

  • Wright State University, Dept. of Biological Sciences. Dayton, OH. April 17, 2012 

  • Nanjing Summit on Viral Oncogenesis ad Drug Discovery and Development. Nanjing, China. 
Sept. 20, 2014 (also served as a “DNA tumor viruses” session chair) 

  • Peking University Health Science Center. Department of Microbiology & Infectious Disease 
Center. Beijing, China. Sept. 22, 2014 


Conference Oral Presentations 

  • “Intracellular trafficking and disassembly of BK virus,” the 27th American Society for Virology Annual Meeting. Ithaca, New York. July 13, 2008 

  • “Intracellular trafficking and disassembly of BK virus,” Molecular Biology of DNA Tumor Viruses Conference. Madison, Wisconsin. July 24, 2008 

  • “Host interactions of BK virus during entry,” the 28th American Society for Virology Annual Meeting. Vancouver, BC, Canada. July 11, 2009

  • “Involvement of the DNA damage response during BK virus infection,” Molecular Biology of DNA Tumor Viruses Conference. Madison, Wisconsin. July 15, 2010 

  • “Functional reorganization of promyelocytic leukemia nuclear bodies during BK virus infection,” the 30th American Society for Virology Annual Meeting. Minneapolis, Minnesota. July 18, 2011

  • “Regulation of the DNA damage response during BK polyomavirus infection,” the 33rd American Society for Virology Annual Meeting. Fort Collins, Colorado. June 22, 2014 

  • “Regulation of the DNA damage response during BK polyomavirus infection,” Molecular Biology of DNA Tumor Viruses Conferences. Madison, Wisconsin. July 20, 2014

  • “Mechanisms of JC polyomavirus penetration of the blood brain barrier,” PML Consortium Symposium. Washington, DC. Oct. 29, 2014

  • “BK polyomavirus and the host DNA damage response,” 3rdASM Conference on Viral Manipulation of Nuclear Processes. Washington, DC. Nov. 1, 2014

  • “Polyomavirus, DNA damage response, and genome instability,” Society of Chinese Bioscientists in America the 15thInternational Symposium. Taipei, 2015 

  • “BK polyomavirus regulation of host DNA damage response and genomeinstability,” ICGEB DNA Tumor Virus Meeting. Trieste, Italy, 2015


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